Indirect bilirubin impairs invasion of osteosarcoma cells via inhibiting the PI3K/AKT/MMP-2 signaling pathway by suppressing intracellular ROS

Indirect bilirubin impairs invasion of osteosarcoma cells via inhibiting the PI3K/AKT/MMP-2 signaling pathway by suppressing intracellular ROS

Background: Osteosarcoma is most prevalently found primary malignant bone tumors, with primary metastatic patients accounting for approximately 25% of all osteosarcoma patients, yet their 5-year OS remains below 30%. Bilirubin plays a key role in oxidative stress-associated events, including maligna...

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Bibliographic Details
Main Authors: Xuhui Yuan, Cong Ma, Jiayu Li, Junhong Li, Ronghui Yu, Feng Cai, Gaoyang Qu, Bo Yu, Lang Liu, Duo Zeng, QuanHui Jiao, Qi Liao, Xiaobin Lv
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Journal of Bone Oncology
Subjects:
Osteosarcoma
IBIL
PI3K/AKT/MMP-2
Invasion
Prognosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2212137423000052

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http://www.sciencedirect.com/science/article/pii/S2212137423000052

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