Phosphoglucose Isomerase Is Important for Aspergillus fumigatus Cell Wall Biogenesis

Phosphoglucose Isomerase Is Important for Aspergillus fumigatus Cell Wall Biogenesis

ABSTRACT Aspergillus fumigatus is a devastating opportunistic fungal pathogen causing hundreds of thousands of deaths every year. Phosphoglucose isomerase (PGI) is a glycolytic enzyme that converts glucose-6-phosphate to fructose-6-phosphate, a key precursor of fungal cell wall biosynthesis. Here, w...

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Bibliographic Details
Main Authors: Yao Zhou, Kaizhou Yan, Qijian Qin, Olawale G. Raimi, Chao Du, Bin Wang, Chukwuemeka Samson Ahamefule, Bartosz Kowalski, Cheng Jin, Daan M. F. van Aalten, Wenxia Fang
Format: Article
Language:English
Published: American Society for Microbiology 2022-08-01
Series:mBio
Subjects:
fungi
Aspergillus fumigatus
carbon flux
cell wall
drug target
phosphoglucose isomerase
Online Access:https://journals.asm.org/doi/10.1128/mbio.01426-22

Internet

https://journals.asm.org/doi/10.1128/mbio.01426-22

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