Immunomodulatory and Antibacterial Effects of Cystatin 9 against Francisella tularensis

Immunomodulatory and Antibacterial Effects of Cystatin 9 against Francisella tularensis

Abstract Cystatin 9 (CST9) is a member of the type 2 cysteine protease inhibitor family, which has been shown to have immunomodulatory effects that restrain inflammation, but its functions against bacterial infections are unknown. Here, we report that purified human recombinant (r)CST9 protects agai...

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Bibliographic Details
Main Authors: Tonyia Eaves-Pyles, Jignesh Patel, Emma Arigi, Yingzi Cong, Anthony Cao, Nisha Garg, Monisha Dhiman, Richard B. Pyles, Bernard Arulanandam, Aaron L. Miller, Vsevolod L. Popov, Lynn Soong, Eric D. Carlsen, Ciro Coletta, Csaba Szabo, Igor C. Almeida
Format: Article
Language:English
Published: BMC 2013-08-01
Series:Molecular Medicine
Subjects:
Cystatin (CST9)
Autophagy
Immune Cell Migration
Monocyte-derived Macrophages (MDM)
D-alanyl-D-alanine Carboxypeptidase
Online Access:https://doi.org/10.2119/molmed.2013.00081

Internet

https://doi.org/10.2119/molmed.2013.00081

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