Lesion of the subthalamic nucleus reverses motor deficits but not death of nigrostriatal dopaminergic neurons in a rat 6-hydroxydopamine-lesion model of Parkinson's disease

Lesion of the subthalamic nucleus reverses motor deficits but not death of nigrostriatal dopaminergic neurons in a rat 6-hydroxydopamine-lesion model of Parkinson's disease

The objective of the present study was to determine whether lesion of the subthalamic nucleus (STN) promoted by N-methyl-D-aspartate (NMDA) would rescue nigrostriatal dopaminergic neurons after unilateral 6-hydroxydopamine (6-OHDA) injection into the medial forebrain bundle (MFB). Initially, 16 mg 6...

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Bibliographic Details
Main Authors: V. Rizelio, R.E. Szawka, L.L. Xavier, M. Achaval, P. Rigon, L. Saur, F. Matheussi, A.M. Delattre, J.A. Anselmo-Franci, M. Meneses, A.C. Ferraz
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2010-01-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Subthalamic nucleus
Parkinson's disease
Substantia nigra pars compacta
6-Hydroxydopamine
Tyrosine hydroxylase immunohistochemistry
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000100012

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000100012

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