Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2

Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2

Tumor initiation, progression and resistance to chemotherapy rely on cancer cells bypassing programmed cell death by apoptosis. We report that unlike other pro-apoptotic proteins, Bim contains two distinct binding sites for the anti-apoptotic proteins Bcl-XL and Bcl-2. These include the BH3 sequence...

Full description

Bibliographic Details
Main Authors: Qian Liu, Elizabeth J Osterlund, Xiaoke Chi, Justin Pogmore, Brian Leber, David William Andrews
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-03-01
Series:eLife
Subjects:
Bcl-2 family proteins
apoptosis
BH3-mimetic drugs
tissue culture cells
fluorescence lifetime imaging
Forster resonance energy transfer
Online Access:https://elifesciences.org/articles/37689

Internet

https://elifesciences.org/articles/37689

Similar Items