Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2

Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2

Tumor initiation, progression and resistance to chemotherapy rely on cancer cells bypassing programmed cell death by apoptosis. We report that unlike other pro-apoptotic proteins, Bim contains two distinct binding sites for the anti-apoptotic proteins Bcl-XL and Bcl-2. These include the BH3 sequence...

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Bibliographic Details
Main Authors:	Qian Liu, Elizabeth J Osterlund, Xiaoke Chi, Justin Pogmore, Brian Leber, David William Andrews
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2019-03-01
Series:	eLife
Subjects:	Bcl-2 family proteins apoptosis BH3-mimetic drugs tissue culture cells fluorescence lifetime imaging Forster resonance energy transfer
Online Access:	https://elifesciences.org/articles/37689

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