Identification of Novel Serodiagnostic Signatures of Typhoid Fever Using a Salmonella Proteome Array

Identification of Novel Serodiagnostic Signatures of Typhoid Fever Using a Salmonella Proteome Array

Current diagnostic tests for typhoid fever, the disease caused by Salmonella Typhi, are poor. We aimed to identify serodiagnostic signatures of typhoid fever by assessing microarray signals to 4,445 S. Typhi antigens in sera from 41 participants challenged with oral S. Typhi. We found broad, heterog...

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Bibliographic Details
Main Authors: Thomas C. Darton, Stephen Baker, Arlo Randall, Sabina Dongol, Abhilasha Karkey, Merryn Voysey, Michael J. Carter, Claire Jones, Krista Trappl, Jozelyn Pablo, Chris Hung, Andy Teng, Adam Shandling, Tim Le, Cassidy Walker, Douglas Molina, Jason Andrews, Amit Arjyal, Buddha Basnyat, Andrew J. Pollard, Christoph J. Blohmke
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Microbiology
Subjects:
Salmonella Typhi
serodiagnostics
antibody response
fever diagnostics
enteric fever
machine learning
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.01794/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2017.01794/full

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