The Calcineurin-NFAT-Angiopoietin-2 Signaling Axis in Lung Endothelium Is Critical for the Establishment of Lung Metastases

The Calcineurin-NFAT-Angiopoietin-2 Signaling Axis in Lung Endothelium Is Critical for the Establishment of Lung Metastases

The premetastatic niche is a predetermined site of metastases, awaiting the influx of tumor cells. However, the regulation of the angiogenic switch at these sites has not been examined. Here, we demonstrate that the calcineurin and nuclear factor of activated T cells (NFAT) pathway is activated spec...

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Bibliographic Details
Main Authors: Takashi Minami, Shuying Jiang, Keri Schadler, Jun-ichi Suehiro, Tsuyoshi Osawa, Yuichi Oike, Mai Miura, Makoto Naito, Tatsuhiko Kodama, Sandra Ryeom
Format: Article
Language:English
Published: Elsevier 2013-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713003835

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http://www.sciencedirect.com/science/article/pii/S2211124713003835

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