Intranasal Delivery of a Silymarin Loaded Microemulsion for the Effective Treatment of Parkinson’s Disease in Rats: Formulation, Optimization, Characterization, and In Vivo Evaluation

Intranasal Delivery of a Silymarin Loaded Microemulsion for the Effective Treatment of Parkinson’s Disease in Rats: Formulation, Optimization, Characterization, and In Vivo Evaluation

A mucoadhesive microemulsion of lipophilic silymarin (SLMMME) was developed to treat Parkinson’s disease (PD). Optimization of the SLM microemulsion (ME) was performed using Central Composite Design (CCD). The composition of oil, surfactant, co-surfactant, and water was varied, as per the design, to...

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Bibliographic Details
Main Authors: Mohd Imran, Mazen Almehmadi, Ahad Amer Alsaiari, Mehnaz Kamal, Mohammed Kanan Alshammari, Mohammed Omar Alzahrani, Faisal Khaled Almaysari, Abdulrahman Omar Alzahrani, Ahmed Faraj Elkerdasy, Sachin Kumar Singh
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Pharmaceutics
Subjects:
lipophilic drug
microemulsion
mucoadhesion
neurodegenerative disease
central composite design
zeta potential
Online Access:https://www.mdpi.com/1999-4923/15/2/618

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https://www.mdpi.com/1999-4923/15/2/618

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