SNAI1-dependent upregulation of CD73 increases extracellular adenosine release to mediate immune suppression in TNBC

SNAI1-dependent upregulation of CD73 increases extracellular adenosine release to mediate immune suppression in TNBC

Triple-negative subtype of breast cancer (TNBC) is hallmarked by frequent disease relapse and shows highest mortality rate. Although PD-1/PD-L1 immune checkpoint blockades have recently shown promising clinical benefits, the overall response rate remains largely insufficient. Hence, alternative ther...

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Bibliographic Details
Main Authors: Meriem Hasmim, Malina Xiao, Kris Van Moer, Akinchan Kumar, Alexandra Oniga, Michel Mittelbronn, Caroline Duhem, Anwar Chammout, Guy Berchem, Jean Paul Thiery, Marianna Volpert, Brett Hollier, Muhammad Zaeem Noman, Bassam Janji
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
CD73
SNAI1
epithelial-to-mesenchymal transition
adenosine
anti-tumor immune response
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.982821/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.982821/full

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