Discovery of RC-752, a Novel Sigma-1 Receptor Antagonist with Antinociceptive Activity: A Promising Tool for Fighting Neuropathic Pain

Discovery of RC-752, a Novel Sigma-1 Receptor Antagonist with Antinociceptive Activity: A Promising Tool for Fighting Neuropathic Pain

Neuropathic pain (NP) is a chronic condition resulting from damaged pain-signaling pathways. It is a debilitating disorder that affects up to 10% of the world’s population. Although opioid analgesics are effective in reducing pain, they present severe risks; so, there is a pressing need for non-opio...

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Bibliographic Details
Main Authors: Giacomo Rossino, Annamaria Marra, Roberta Listro, Marco Peviani, Elena Poggio, Daniela Curti, Giorgia Pellavio, Umberto Laforenza, Giulio Dondio, Dirk Schepmann, Bernhard Wünsch, Martina Bedeschi, Noemi Marino, Anna Tesei, Hee-Jin Ha, Young-Ho Kim, Jihyae Ann, Jeewoo Lee, Pasquale Linciano, Marcello Di Giacomo, Daniela Rossi, Simona Collina
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Pharmaceuticals
Subjects:
sigma 1 receptor antagonist
neuropathic pain
antinociceptive activity
zebrafish model
Online Access:https://www.mdpi.com/1424-8247/16/7/962

Internet

https://www.mdpi.com/1424-8247/16/7/962

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