Inhibition of Aldose Reductase by Ginsenoside Derivatives via a Specific Structure Activity Relationship with Kinetics Mechanism and Molecular Docking Study

Inhibition of Aldose Reductase by Ginsenoside Derivatives via a Specific Structure Activity Relationship with Kinetics Mechanism and Molecular Docking Study

This present work is designed to evaluate the anti-diabetic potential of 22 ginsenosides via the inhibition against rat lens aldose reductase (RLAR), and human recombinant aldose reductase (HRAR), using <sub>DL</sub>-glyceraldehyde as a substrate. Among the ginsenosides tested, ginsenosi...

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Bibliographic Details
Main Authors: Md Yousof Ali, Sumera Zaib, Susoma Jannat, Imtiaz Khan, M. Mizanur Rahman, Seong Kyu Park, Mun Seog Chang
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Molecules
Subjects:
ginsenosides
diabetic complication
aldose reductase
enzyme kinetics
molecular docking
sorbitol accumulation
Online Access:https://www.mdpi.com/1420-3049/27/7/2134

Internet

https://www.mdpi.com/1420-3049/27/7/2134

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