Inhibition of Aldose Reductase by Ginsenoside Derivatives via a Specific Structure Activity Relationship with Kinetics Mechanism and Molecular Docking Study

Inhibition of Aldose Reductase by Ginsenoside Derivatives via a Specific Structure Activity Relationship with Kinetics Mechanism and Molecular Docking Study

This present work is designed to evaluate the anti-diabetic potential of 22 ginsenosides via the inhibition against rat lens aldose reductase (RLAR), and human recombinant aldose reductase (HRAR), using <sub>DL</sub>-glyceraldehyde as a substrate. Among the ginsenosides tested, ginsenosi...

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Bibliographic Details
Main Authors:	Md Yousof Ali, Sumera Zaib, Susoma Jannat, Imtiaz Khan, M. Mizanur Rahman, Seong Kyu Park, Mun Seog Chang
Format:	Article
Language:	English
Published:	MDPI AG 2022-03-01
Series:	Molecules
Subjects:	ginsenosides diabetic complication aldose reductase enzyme kinetics molecular docking sorbitol accumulation
Online Access:	https://www.mdpi.com/1420-3049/27/7/2134

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