The Dopamine Allosteric Agent, PAOPA, Demonstrates Therapeutic Potential in the Phencyclidine NMDA Pre-clinical Rat Model of Schizophrenia

The Dopamine Allosteric Agent, PAOPA, Demonstrates Therapeutic Potential in the Phencyclidine NMDA Pre-clinical Rat Model of Schizophrenia

PAOPA, a potent analog of prolyl-leucyl-glycinamide, has shown therapeutic potential at the preclinical stage for dopaminergic related illnesses, including animal models of schizophrenia, Parkinson’s disease and haloperidol-induced extrapyramidal movement disorders. PAOPA’s unique allosteric mechani...

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Bibliographic Details
Main Authors: Ritesh P. Daya, Jayant Bhandari, Sharnpreet K. Kooner, Joella Ho, Christopher D. Rowley, Nicholas A. Bock, Troy Farncombe, Ram K. Mishra
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
allosteric modulator
dopamine
NMDA
phencyclidine
rat model
schizophrenia
Online Access:https://www.frontiersin.org/article/10.3389/fnbeh.2018.00302/full

Internet

https://www.frontiersin.org/article/10.3389/fnbeh.2018.00302/full

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