Interleukin-21 receptor signaling promotes metabolic dysfunction-associated steatohepatitis-driven hepatocellular carcinoma by inducing immunosuppressive IgA+ B cells

Interleukin-21 receptor signaling promotes metabolic dysfunction-associated steatohepatitis-driven hepatocellular carcinoma by inducing immunosuppressive IgA+ B cells

Abstract Background Dysregulation of immune surveillance is tightly linked to the development of metabolic dysfunction-associated steatohepatitis (MASH)-driven hepatocellular carcinoma (HCC); however, its underlying mechanisms remain unclear. Herein, we aimed to determine the role of interleukin-21...

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Bibliographic Details
Main Authors: Ying Xie, Yu Huang, Zhi-Yong Li, Weihua Jiang, Nan-Xi Shi, Yuanzhi Lu, Guangchao Cao, Zhinan Yin, Xue-Jia Lin
Format: Article
Language:English
Published: BMC 2024-05-01
Series:Molecular Cancer
Subjects:
IL-21R
MASH-driven HCC
IgA+ B cell
Cancer-promoting role
Online Access:https://doi.org/10.1186/s12943-024-02001-2

Internet

https://doi.org/10.1186/s12943-024-02001-2

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