Epigenetic repression of de novo cysteine synthetases induces intra-cellular accumulation of cysteine in hepatocarcinoma by up-regulating the cystine uptake transporter xCT

Epigenetic repression of de novo cysteine synthetases induces intra-cellular accumulation of cysteine in hepatocarcinoma by up-regulating the cystine uptake transporter xCT

Abstract Background The metabolic reprogramming of amino acids is critical for cancer cell growth and survival. Notably, intracellular accumulation of cysteine is often observed in various cancers, suggesting its potential role in alleviating the oxidative stress associated with rapid proliferation....

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Bibliographic Details
Main Authors: Tomoaki Yamauchi, Yumi Okano, Daishu Terada, Sai Yasukochi, Akito Tsuruta, Yuya Tsurudome, Kentaro Ushijima, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo
Format: Article
Language:English
Published: BMC 2024-08-01
Series:Cancer & Metabolism
Subjects:
Cysteine metabolism
xCT
de novo cysteine synthesis
Hepatocarcinoma
DNA methylation
NRF2
Online Access:https://doi.org/10.1186/s40170-024-00352-4

Internet

https://doi.org/10.1186/s40170-024-00352-4

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