Molecular Analysis and Conformational Dynamics of Human MC4R Disease-Causing Mutations

Molecular Analysis and Conformational Dynamics of Human MC4R Disease-Causing Mutations

Obesity is a chronic disease with increasing cases among children and adolescents. Melanocortin 4 receptor (MC4R) is a G protein-coupled transporter involved in solute transport, enabling it to maintain cellular homeostasis. MC4R mutations are associated with early-onset severe obesity, and the iden...

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Bibliographic Details
Main Authors: Munazza Tamkeen Fatima, Zeyaul Islam, Prasanna R. Kolatkar, Ammira Sarah Al-Shabeeb Akil
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Molecules
Subjects:
MC4R
G protein-coupled transporter (GPCR)
obesity
pathological variants
mutational analysis
simulation
Online Access:https://www.mdpi.com/1420-3049/27/13/4037

Internet

https://www.mdpi.com/1420-3049/27/13/4037

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