Hybrid neural network approaches to predict drug–target binding affinity for drug repurposing: screening for potential leads for Alzheimer’s disease

Hybrid neural network approaches to predict drug–target binding affinity for drug repurposing: screening for potential leads for Alzheimer’s disease

Alzheimer’s disease (AD) is a neurodegenerative disease that primarily affects elderly individuals. Recent studies have found that sigma-1 receptor (S1R) agonists can maintain endoplasmic reticulum stress homeostasis, reduce neuronal apoptosis, and enhance mitochondrial function and autophagy, makin...

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Bibliographic Details
Main Authors: Xialin Wu, Zhuojian Li, Guanxing Chen, Yiyang Yin, Calvin Yu-Chian Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Molecular Biosciences
Subjects:
Alzheimer’s disease
drug repurposing
hybrid neural network
molecular docking
sigma-1 receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1227371/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2023.1227371/full

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