PL1 Peptide Engages Acidic Surfaces on Tumor-Associated Fibronectin and Tenascin Isoforms to Trigger Cellular Uptake

PL1 Peptide Engages Acidic Surfaces on Tumor-Associated Fibronectin and Tenascin Isoforms to Trigger Cellular Uptake

Tumor extracellular matrix (ECM) is a high-capacity target for the precision delivery of affinity ligand-guided drugs and imaging agents. Recently, we developed a PL1 peptide (sequence: PPRRGLIKLKTS) for systemic targeting of malignant ECM. Here, we map the dynamics of PL1 binding to its receptors F...

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Bibliographic Details
Main Authors: Prakash Lingasamy, Kristina Põšnograjeva, Sergei Kopanchuk, Allan Tobi, Ago Rinken, Ignacio J. General, Eliana K. Asciutto, Tambet Teesalu
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Pharmaceutics
Subjects:
tumor homing peptide
fibronectin
Tenascin-C
molecular docking
molecular dynamics simulations
glioblastoma
Online Access:https://www.mdpi.com/1999-4923/13/12/1998

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https://www.mdpi.com/1999-4923/13/12/1998

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