Dysregulation of TSP2-Rac1-WAVE2 axis in diabetic cells leads to cytoskeletal disorganization, increased cell stiffness, and dysfunction

Dysregulation of TSP2-Rac1-WAVE2 axis in diabetic cells leads to cytoskeletal disorganization, increased cell stiffness, and dysfunction

Abstract Fibroblasts are a major cell population that perform critical functions in the wound healing process. In response to injury, they proliferate and migrate into the wound space, engaging in extracellular matrix (ECM) production, remodeling, and contraction. However, there is limited knowledge...

Full description

Bibliographic Details
Main Authors: Hao Xing, Yaqing Huang, Britta H. Kunkemoeller, Peter J. Dahl, Ohvia Muraleetharan, Nikhil S. Malvankar, Michael P. Murrell, Themis R. Kyriakides
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-26337-1

Internet

https://doi.org/10.1038/s41598-022-26337-1

Similar Items