Comparison of the immunogenicity of different therapeutic preparations of human factor VIII in the murine model of hemophilia A

Comparison of the immunogenicity of different therapeutic preparations of human factor VIII in the murine model of hemophilia A

Von Willebrand factor (VWF) has been proposed to reduce the immunogenicity of therapeutic factor VIII (FVIII) in patients with hemophilia A. Using FVIII-deficient mice, we compared the immunogenicity of different preparations of plasma-derived (pd) and recombinant (r) FVIII. Treatment of mice with p...

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Main Authors: Sandrine Delignat, Suryasarathi Dasgupta, Sébastien André, Ana-Maria Navarrete, Srinivas V. Kaveri, Jagadeesh Bayry, Marie-Hélène André, Sami Chtourou, Zéra Tellier, Sébastien Lacroix-Desmazes
Format: Article
Language:English
Published: Ferrata Storti Foundation 2007-10-01
Series:Haematologica
Online Access:https://haematologica.org/article/view/4611

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https://haematologica.org/article/view/4611

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