Diosgenin enhances liposome-enabled nucleic acid delivery and CRISPR/Cas9-mediated gene editing by modulating endocytic pathways

Diosgenin enhances liposome-enabled nucleic acid delivery and CRISPR/Cas9-mediated gene editing by modulating endocytic pathways

The CRISPR/Cas9 system holds great promise in treating genetic diseases, owing to its safe and precise genome editing. However, the major challenges to implementing the technology in clinics lie in transiently limiting the expression of genome editing factors and achieving therapeutically relevant f...

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Bibliographic Details
Main Authors: Brijesh Lohchania, Abisha Crystal Christopher, Porkizhi Arjunan, Gokulnath Mahalingam, Durga Kathirvelu, Aishwarya Prasannan, Vigneshwaran Venkatesan, Pankaj Taneja, Mohan Kumar KM, Saravanabhavan Thangavel, Srujan Marepally
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
CRISPR/Cas9
cationic lipid
diosgenin
transfections
genome editing
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2022.1031049/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2022.1031049/full

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