Nrf2 induces malignant transformation of hepatic progenitor cells by inducing β-catenin expression

Nrf2 induces malignant transformation of hepatic progenitor cells by inducing β-catenin expression

The Nrf2 signaling pathway prevents cancer initiation, but genetic mutations that activate this pathway are found in various types of cancer. The molecular mechanisms underlying this Janus-headed character are still not understood. Here, we show that sustained Nrf2 activation induces proliferation a...

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Bibliographic Details
Main Authors: Athanassios Fragoulis, Julia Schenkel, Nicole Schröder, Elisa Fabiana Brandt, Mathias Weiand, Tabita Neu, Pierluigi Ramadori, Tim Caspers, Sebastian Kant, Thomas Pufe, Antje Mohs, Christian Trautwein, Thomas Longerich, Konrad Ludwig Streetz, Christoph Jan Wruck
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722002257

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http://www.sciencedirect.com/science/article/pii/S2213231722002257

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