Methionine Metabolism Is Down-Regulated in Heart of Long-Lived Mammals

Methionine Metabolism Is Down-Regulated in Heart of Long-Lived Mammals

Methionine constitutes a central hub of intracellular metabolic adaptations leading to an extended longevity (maximum lifespan). The present study follows a comparative approach analyzing methionine and related metabolite and amino acid profiles using an LC-MS/MS platform in the hearts of seven mamm...

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Bibliographic Details
Main Authors: Natalia Mota-Martorell, Mariona Jové, Rebeca Berdún, Èlia Òbis, Gustavo Barja, Reinald Pamplona
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Biology
Subjects:
amino acids
methionine
longevity
mass spectrometry
transmethylation pathway
transsulfuration pathway
Online Access:https://www.mdpi.com/2079-7737/11/12/1821

Internet

https://www.mdpi.com/2079-7737/11/12/1821

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