Ligand-Based Discovery of a Small Molecule as Inhibitor of α-Synuclein Amyloid Formation

Ligand-Based Discovery of a Small Molecule as Inhibitor of α-Synuclein Amyloid Formation

α-Synuclein (α-Syn) aggregates are implicated in Parkinson’s disease (PD), so inhibitors of α-Syn aggregation have been intensively explored. It has been demonstrated that small molecules might be able to reduce α-Syn aggregation in fibrils, thus exerting neuroprotective effects in models of PD. To...

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Bibliographic Details
Main Authors: Laura De Luca, Serena Vittorio, Samuel Peña-Díaz, Giovanna Pitasi, Marc Fornt-Suñé, Federica Bucolo, Salvador Ventura, Rosaria Gitto
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
alpha-synuclein
Parkinson’s disease
small molecule
virtual screening
binding site prediction
Th-T fluorescence assay
Online Access:https://www.mdpi.com/1422-0067/23/23/14844

Internet

https://www.mdpi.com/1422-0067/23/23/14844

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