Increased vulnerability of nigrostriatal terminals in DJ-1-deficient mice is mediated by the dopamine transporter

Increased vulnerability of nigrostriatal terminals in DJ-1-deficient mice is mediated by the dopamine transporter

Mutations in the gene for DJ-1 have been associated with early-onset autosomal recessive parkinsonism. Previous studies of null DJ-1 mice have shown alterations in striatal dopamine (DA) transmission with no DAergic cell loss. Here we characterize a new line of DJ-1-deficient mice. A subtle locomoto...

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Bibliographic Details
Main Authors: Amy B. Manning-Boğ, W. Michael Caudle, Xiomara A. Perez, Stephen H. Reaney, Ronald Paletzki, Martha Z. Isla, Vivian P. Chou, Alison L. McCormack, Gary W. Miller, J. William Langston, Charles R. Gerfen, Donato A. DiMonte
Format: Article
Language:English
Published: Elsevier 2007-08-01
Series:Neurobiology of Disease
Subjects:
DJ-1
Parkinson
Dopamine transporter
Striatum
MPTP
Substantia nigra
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996107000770

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http://www.sciencedirect.com/science/article/pii/S0969996107000770

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