Quantitative multiplex immunofluorescence analysis identifies infiltrating PD1+CD8+ and CD8+ T cells as predictive of response to neoadjuvant chemotherapy in breast cancer

Quantitative multiplex immunofluorescence analysis identifies infiltrating PD1+CD8+ and CD8+ T cells as predictive of response to neoadjuvant chemotherapy in breast cancer

Background This study aimed to explore the potentially predictive role and dynamic changes of immune checkpoints on T cell subsets in patients with breast cancer receiving neoadjuvant chemotherapies. Methods Fluorescent multiplex immunohistochemistry (mIHC) was used to stain CD4, CD8, PD1, TIM3, and...

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Bibliographic Details
Main Authors: Hongling Liang, Hongsheng Li, Zhi Xie, Tianen Jin, Yu Chen, Zhiyi Lv, Xiaojun Tan, Jia Li, Guodong Han, Weixing He, Ni Qiu, Ming Jiang, Jie Zhou, Haoming Xia, Yongtao Zhan, Lulu Cui, Weiling Guo, Jianqing Huang, Xuchao Zhang, Yi‐long Wu
Format: Article
Language:English
Published: Wiley 2020-10-01
Series:Thoracic Cancer
Subjects:
Breast cancer
neoadjuvant chemotherapy
PD1
T cell
tumor‐infiltrating lymphocytes
Online Access:https://doi.org/10.1111/1759-7714.13639

Internet

https://doi.org/10.1111/1759-7714.13639

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