Nuclear trapping of inactive FOXO1 by the Nrf2 activator diethyl maleate

Nuclear trapping of inactive FOXO1 by the Nrf2 activator diethyl maleate

Diethyl maleate (DEM), a thiol-reactive α,β-unsaturated carbonyl compound, depletes glutathione (GSH) in exposed cells and was previously shown by us to elicit a stress response in Caenorhabditis elegans that, at lower concentrations, results in enhanced stress resistance and longer lifespan. This h...

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Bibliographic Details
Main Authors: Andrea Gille, Abdullah Turkistani, Dimitrios Tsitsipatis, Xiaoqing Hou, Sarah Tauber, Ingrit Hamann, Nadine Urban, Katrin Erler, Holger Steinbrenner, Lars-Oliver Klotz
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231718307432

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http://www.sciencedirect.com/science/article/pii/S2213231718307432

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