XIAP as a Target of New Small Organic Natural Molecules Inducing Human Cancer Cell Death

XIAP as a Target of New Small Organic Natural Molecules Inducing Human Cancer Cell Death

X-linked inhibitor of apoptosis protein (XIAP) is an emerging crucial therapeutic target in cancer. We report on the discovery and characterisation of small organic molecules from <i>Piper</i> genus plants exhibiting XIAP antagonism, namely erioquinol, a quinol substituted in the 4-posit...

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Bibliographic Details
Main Authors: Diego Muñoz, Martina Brucoli, Silvia Zecchini, Adrian Sandoval-Hernandez, Gonzalo Arboleda, Fabian Lopez-Vallejo, Wilman Delgado, Matteo Giovarelli, Marco Coazzoli, Elisabetta Catalani, Clara De Palma, Cristiana Perrotta, Luis Cuca, Emilio Clementi, Davide Cervia
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cancers
Subjects:
phytochemicals
small organic agents
<i>Piper eriopodon</i>, alkenylphenols
human cancer cells
cell death
apoptosis
caspase-independent cell death
XIAP antagonists
XIAP-BIR3 domain
Online Access:https://www.mdpi.com/2072-6694/11/9/1336

Internet

https://www.mdpi.com/2072-6694/11/9/1336

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