Evolution of Virulence, Fitness, and Carbapenem Resistance Transmission in ST23 Hypervirulent Klebsiella pneumoniae with the Capsular Polysaccharide Synthesis Gene wcaJ Inserted via Insertion Sequence Elements

Evolution of Virulence, Fitness, and Carbapenem Resistance Transmission in ST23 Hypervirulent Klebsiella pneumoniae with the Capsular Polysaccharide Synthesis Gene wcaJ Inserted via Insertion Sequence Elements

ABSTRACT Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) is recognized as a threat worldwide, but the mechanisms underlying its emergence remain unclear. As most CR-hvKP isolates are not hypermucoviscous, we speculated that the evolution of the capsule might result in the converge...

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Bibliographic Details
Main Authors: Shuyi Wang, Qi Ding, Yawei Zhang, Anru Zhang, Qi Wang, Ruobing Wang, Xiaojuan Wang, Longyang Jin, Shuai Ma, Hui Wang
Format: Article
Language:English
Published: American Society for Microbiology 2022-12-01
Series:Microbiology Spectrum
Subjects:
carbapenem-resistant hypervirulent Klebsiella pneumoniae
CR-hvKP
capsule
conjugation
insertion sequences
IS
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02400-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.02400-22

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