Improved detection of familial hypercholesterolemia by determining low density lipoprotein receptor expression in mitogen-induced proliferating lymphocytes

Improved detection of familial hypercholesterolemia by determining low density lipoprotein receptor expression in mitogen-induced proliferating lymphocytes

In view of the presence of some 190 mutations in the low density lipoprotein receptor (LDL-R) gene and a lack of simple detection methods, we have developed an improved assay system for detecting familial hypercholesterolemia (FH) using mitogen-induced proliferating lymphocytes. Freshly isolated mon...

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Bibliographic Details
Main Authors: Pak-cheung Chan, Alun Edwards, René Lafrenière, Howard G. Parsons
Format: Article
Language:English
Published: Elsevier 1998-11-01
Series:Journal of Lipid Research
Subjects:
familial hypercholesterolemia
low density lipoprotein receptor
proliferating lymphocytes
mitogen stimulation
flow cytometry
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520324810

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http://www.sciencedirect.com/science/article/pii/S0022227520324810

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