Fabrication of Nanocrystals for Enhanced Distribution of a Fatty Acid Synthase Inhibitor (Orlistat) as a Promising Method to Relieve Solid Ehrlich Carcinoma-Induced Hepatic Damage in Mice

Fabrication of Nanocrystals for Enhanced Distribution of a Fatty Acid Synthase Inhibitor (Orlistat) as a Promising Method to Relieve Solid Ehrlich Carcinoma-Induced Hepatic Damage in Mice

Background: Orlistat (ORL) is an effective irreversible inhibitor of the lipase enzyme, and it possesses anticancer effects and limited aqueous solubility. This study was designed to improve the aqueous solubility, oral absorption, and tissue distribution of ORL via the formulation of nanocrystals (...

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Bibliographic Details
Main Authors: Jawaher Abdullah Alamoudi, Thanaa A. El-Masry, Mohamed Nasr, Ismail T. Ibrahim, Hanaa A. Ibrahim, Hebatallah M. Saad, Maysa M. F. El-Nagar, Samar Zuhair Alshawwa, Amal Alrashidi, Enas I. El Zahaby
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Pharmaceuticals
Subjects:
bioavailability
biodistribution
nanocrystals
liver damage
orlistat
radiolabeling
Online Access:https://www.mdpi.com/1424-8247/17/1/96

Internet

https://www.mdpi.com/1424-8247/17/1/96

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