Endurance exercise has a negative impact on the onset of SOD1-G93A ALS in female mice and affects the entire skeletal muscle-motor neuron axis

Endurance exercise has a negative impact on the onset of SOD1-G93A ALS in female mice and affects the entire skeletal muscle-motor neuron axis

Background:Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disease characterized by the degeneration of motor neurons that leads to muscle wasting and atrophy. Epidemiological and experimental evidence suggests a causal relationship between ALS and physical activity (PA). However, the i...

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Bibliographic Details
Main Authors: Silvia Scaricamazza, Valentina Nesci, Illari Salvatori, Gianmarco Fenili, Marco Rosina, Michela Gloriani, Maria Paola Paronetto, Luca Madaro, Alberto Ferri, Cristiana Valle
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Pharmacology
Subjects:
amyotrophic lateral sclerosis
physical activity
endurance exercise
neurodegeneration
neuroinflammation
SOD1-G93A mice
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1360099/full

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https://www.frontiersin.org/articles/10.3389/fphar.2024.1360099/full

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