Phosphodiesterase 10A (PDE10A) localization in the R6/2 mouse model of Huntington's disease

Phosphodiesterase 10A (PDE10A) localization in the R6/2 mouse model of Huntington's disease

In Huntington's disease (HD) mutant huntingtin protein impairs the function of several transcription factors, in particular the cAMP response element-binding protein (CREB). CREB activation can be increased by targeting phosphodiesterases such as phospohodiesterase 4 (PDE4) and phosphodiesteras...

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Bibliographic Details
Main Authors: Alessandro Leuti, Daunia Laurenti, Carmela Giampà, Elena Montagna, Clemente Dato, Serenella Anzilotti, Mariarosa A.B. Melone, Giorgio Bernardi, Francesca R. Fusco
Format: Article
Language:English
Published: Elsevier 2013-04-01
Series:Neurobiology of Disease
Subjects:
Huntington's disease
PDE10A
Striatum
Immunohistochemistry
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112003798

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http://www.sciencedirect.com/science/article/pii/S0969996112003798

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