Sustained notch signaling inhibition with a gamma-secretase inhibitor prevents traumatic heterotopic ossification

Sustained notch signaling inhibition with a gamma-secretase inhibitor prevents traumatic heterotopic ossification

Background: Traumatic heterotopic ossification (THO) is a devastating sequela following traumatic injuries and orthopedic surgeries. To date, the exact molecular mechanism of THO formation is still unclear, which hinders the development of effective treatments. The process of THO formation is believ...

Full description

Bibliographic Details
Main Authors: Zheng Wang, Xinzeyu Yi, Chao Jian, Baiwen Qi, Qiaoyun Liu, Zonghuan Li, Aixi Yu
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Journal of Orthopaedic Translation
Subjects:
Traumatic heterotopic ossification
Notch signaling
Gamma-secretase
Tissue-resident mesenchymal progenitor cells
Differentiation
Proliferation
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X23000475

Internet

http://www.sciencedirect.com/science/article/pii/S2214031X23000475

Similar Items