Enaminone-based carboxylic acids as novel non-classical carbonic anhydrases inhibitors: design, synthesis and in vitro biological assessment

Enaminone-based carboxylic acids as novel non-classical carbonic anhydrases inhibitors: design, synthesis and in vitro biological assessment

In searching for new molecular drug targets, Carbonic Anhydrases (CAs) have emerged as valuable targets in diverse diseases. CAs play critical functions in maintaining pH and CO2 homeostasis, metabolic pathways, and much more. So, it is becoming attractive for medicinal chemists to design novel inhi...

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Bibliographic Details
Main Authors: Mahmoud F. Abo-Ashour, Hadia Almahli, Alessandro Bonardia, Amira Khalil, Tarfah Al-Warhi, Sara T. Al-Rashood, Hatem A. Abdel-Aziz, Alessio Nocentini, Claudiu T. Supuran, Wagdy M. Eldehna
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Carbonic anhydrase
H-NMR
enaminone
stopped-flow assay
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2022.2114079

Internet

https://www.tandfonline.com/doi/10.1080/14756366.2022.2114079

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