A new cirrhotic animal protocol combining carbon tetrachloride with methotrexate to address limitations of the currently used chemical-induced models

A new cirrhotic animal protocol combining carbon tetrachloride with methotrexate to address limitations of the currently used chemical-induced models

Background: Chemically induced cirrhotic animal models are commonly used. However, they have limitations such as high mortalities and low yield of cirrhotic animals that limit their uses.Aims: To overcome limitations of the chemically induced cirrhotic animal model via combined administration of met...

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Bibliographic Details
Main Authors: Rasha A. Mansouri, Adel M. Ahmed, Huda F. Alshaibi, Maha M. Al-Bazi, Abeer A. Banjabi, Hadeil Muhanna Alsufiani, Akram Ahmed Aloqbi, Esam M. Aboubakr
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Pharmacology
Subjects:
liver cirrhosis
carbon tetrachloride
methotrexate
cirrhotic animal model
micellar liquid chromatography
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1201583/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1201583/full

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