Dorsolateral Prefrontal Cortex Glutamate/Gamma-Aminobutyric Acid (GABA) Alterations in Clinical High Risk and First-Episode Schizophrenia: A Preliminary 7-T Magnetic Resonance Spectroscopy Imaging Study

Dorsolateral Prefrontal Cortex Glutamate/Gamma-Aminobutyric Acid (GABA) Alterations in Clinical High Risk and First-Episode Schizophrenia: A Preliminary 7-T Magnetic Resonance Spectroscopy Imaging Study

Converging lines of evidence suggest that an imbalance between excitation and inhibition is present in the dorsolateral prefrontal cortex (DLPFC) of schizophrenia (SCZ). Gamma-aminobutyric-acid (GABA) and, to a lesser extent, glutamate (Glu) abnormalities were reported in the DLPFC of SCZ patients,...

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Bibliographic Details
Main Authors: Ahmad Mayeli, Susan F. Sonnenschein, Victor E. Yushmanov, James D. Wilson, Annie Blazer, William Foran, Maria Perica, Finnegan J. Calabro, Beatriz Luna, Hoby P. Hetherington, Deepak K. Sarpal, Fabio Ferrarelli
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
dorsolateral prefrontal cortex
DLPFC
first episode schizophrenia
gamma-aminobutyric acid
GABA
clinical high risk for psychosis
Online Access:https://www.mdpi.com/1422-0067/23/24/15846

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https://www.mdpi.com/1422-0067/23/24/15846

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