Repurposing DrugBank compounds as potential Plasmodium falciparum class 1a aminoacyl tRNA synthetase multi-stage pan-inhibitors with a specific focus on mitomycin

Repurposing DrugBank compounds as potential Plasmodium falciparum class 1a aminoacyl tRNA synthetase multi-stage pan-inhibitors with a specific focus on mitomycin

Plasmodium falciparum aminoacyl tRNA synthetases (PfaaRSs) are potent antimalarial targets essential for proteome fidelity and overall parasite survival in every stage of the parasite's life cycle. So far, some of these proteins have been singly targeted yielding inhibitor compounds that have b...

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Bibliographic Details
Main Authors: Fisayo Olotu, Mariscal Brice Tchatat Tali, Curtis Chepsiror, Olivier Sheik Amamuddy, Fabrice Fekam Boyom, Özlem Tastan Bishop
Format: Article
Language:English
Published: Elsevier 2024-08-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Subjects:
Plasmodium falciparum
tRNA synthetases
Structure-based drug discovery
Malaria
Mitomycin
Pan-inhibition
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320724000290

Internet

http://www.sciencedirect.com/science/article/pii/S2211320724000290

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