Cysteine 467 of the ASCT2 Amino Acid Transporter Is a Molecular Determinant of the Antiport Mechanism

Cysteine 467 of the ASCT2 Amino Acid Transporter Is a Molecular Determinant of the Antiport Mechanism

The plasma membrane transporter ASCT2 is a well-known Na<sup>+</sup>-dependent obligatory antiporter of neutral amino acids. The crucial role of the residue C467 in the recognition and binding of the ASCT2 substrate glutamine, has been highlighted by structure/function relationship studi...

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Bibliographic Details
Main Authors: Mariafrancesca Scalise, Gilda Pappacoda, Tiziano Mazza, Lara Console, Lorena Pochini, Cesare Indiveri
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
amino acid
glutamine
transport
over-expression
liposome
site-directed mutant
Online Access:https://www.mdpi.com/1422-0067/23/3/1127

Internet

https://www.mdpi.com/1422-0067/23/3/1127

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