Glycosylation of Twisted gastrulation is required for BMP binding and activity during craniofacial development

Glycosylation of Twisted gastrulation is required for BMP binding and activity during craniofacial development

Twisted Gastrulation (TWSG1) is a conserved, secreted glycoprotein that modulates signaling of bone morphogenetic proteins (BMPs) in the extracellular space. Deletion of exon 4 of mouse Twsg1 (mTwsg1) is associated with significant craniofacial defects. However, little is understood about the bioche...

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Bibliographic Details
Main Authors: Charles J. Billington, Juliane eFiebig, Cynthia L. Forsman, Lan ePham, Nathan eBurbach, Mu eSun, Tina eJaskoll, Kim eMansky, Rajaram eGopalakrishnan, Michael B. O'Connor, Thomas eMueller, Anna ePetryk
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-09-01
Series:Frontiers in Physiology
Subjects:
Glycosylation
BMP
Mandibular explants
MSX2
Surface plasmon resonance analysis
Twisted gastrulation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2011.00059/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2011.00059/full

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