Hedgehog-GLI and Notch Pathways Sustain Chemoresistance and Invasiveness in Colorectal Cancer and Their Inhibition Restores Chemotherapy Efficacy

Hedgehog-GLI and Notch Pathways Sustain Chemoresistance and Invasiveness in Colorectal Cancer and Their Inhibition Restores Chemotherapy Efficacy

Colorectal cancer (CRC) is a leading cause of cancer-related mortality and chemoresistance is a major medical issue. The epithelial-to-mesenchymal transition (EMT) is the primary step in the emergence of the invasive phenotype and the Hedgehog-GLI (HH-GLI) and NOTCH signaling pathways are associated...

Full description

Bibliographic Details
Main Authors: Anna Citarella, Giuseppina Catanzaro, Zein Mersini Besharat, Sofia Trocchianesi, Federica Barbagallo, Giorgio Gosti, Marco Leonetti, Annamaria Di Fiore, Lucia Coppola, Tanja Milena Autilio, Zaira Spinello, Alessandra Vacca, Enrico De Smaele, Mary Anna Venneri, Elisabetta Ferretti, Laura Masuelli, Agnese Po
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Cancers
Subjects:
colorectal cancer
signaling pathways
chemoresistance
epithelial-to-mesenchymal transition
organoids
Online Access:https://www.mdpi.com/2072-6694/15/5/1471

Internet

https://www.mdpi.com/2072-6694/15/5/1471

Similar Items