Delivery of Protein Kinase A by CRISPRMAX and Its Effects on Breast Cancer Stem-Like Properties

Delivery of Protein Kinase A by CRISPRMAX and Its Effects on Breast Cancer Stem-Like Properties

Protein kinase A (PKA) activation has recently been reported to inhibit epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC) ability, which is considered to be responsible for chemoresistance and tumor recurrence in patients. While current studies mainly focus on gene manipulation of t...

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Bibliographic Details
Main Authors: Jun-Nian Zhou, Tzu-Chen Rautio, Chang Liu, Xiao-Yu Xu, Dong-Qing Wang, Yong Guo, John Eriksson, Hongbo Zhang
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Pharmaceutics
Subjects:
CRISPRMAX
drug delivery
protein kinase A
chemoresistance
cancer stem cells
epithelial-mesenchymal transition
Online Access:https://www.mdpi.com/1999-4923/13/1/11

Internet

https://www.mdpi.com/1999-4923/13/1/11

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