Excavatolide-B Enhances Contextual Memory Retrieval via Repressing the Delayed Rectifier Potassium Current in the Hippocampus

Excavatolide-B Enhances Contextual Memory Retrieval via Repressing the Delayed Rectifier Potassium Current in the Hippocampus

Memory retrieval dysfunction is a symptom of schizophrenia, autism spectrum disorder (ASD), and absence epilepsy (AE), as well as an early sign of Alzheimer’s disease. To date, few drugs have been reported to enhance memory retrieval. Here, we found that a coral-derived natural product, ex...

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Bibliographic Details
Main Authors: Irene Y. Huang, Yu-Luan Hsu, Chien-Chang Chen, Mei-Fang Chen, Zhi-Hong Wen, Hsien-Ting Huang, Ingrid Y. Liu
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Marine Drugs
Subjects:
coral
excavatolide-B
<i>Ca<sub>v</sub>3.2<sup>−/−</sup></i> mice
T-type calcium channel
potassium current
long-term potentiation
autism spectrum disorder
absence epilepsy
memory
Online Access:https://www.mdpi.com/1660-3397/16/11/405

Internet

https://www.mdpi.com/1660-3397/16/11/405

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