A Stage-Specific OTX2 Regulatory Network and Maturation-Associated Gene Programs Are Inherent Barriers to RPE Neural Competency

A Stage-Specific OTX2 Regulatory Network and Maturation-Associated Gene Programs Are Inherent Barriers to RPE Neural Competency

The retinal pigment epithelium (RPE) exhibits a diverse range of plasticity across vertebrates and is a potential source of cells for the regeneration of retinal neurons. Embryonic amniotes possess a transitory ability to regenerate neural retina through the reprogramming of RPE cells in an FGF-depe...

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Bibliographic Details
Main Authors: Jared A. Tangeman, J. Raúl Pérez-Estrada, Emily Van Zeeland, Lin Liu, Alexandra Danciutiu, Erika Grajales-Esquivel, Byran Smucker, Chun Liang, Katia Del Rio-Tsonis
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
RPE
retina
ATAC-seq
reprogramming
regeneration
Otx2
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.875155/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.875155/full

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