As in Real Estate, Location Matters: Cellular Expression of Complement Varies Between Macular and Peripheral Regions of the Retina and Supporting Tissues

As in Real Estate, Location Matters: Cellular Expression of Complement Varies Between Macular and Peripheral Regions of the Retina and Supporting Tissues

The cellular events that dictate the initiation of the complement pathway in ocular degeneration, such as age-related macular degeneration (AMD), is poorly understood. Using gene expression analysis (single cell and bulk), mass spectrometry, and immunohistochemistry, we dissected the role of multipl...

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Bibliographic Details
Main Authors: Randy Zauhar, Josef Biber, Yassin Jabri, Mijin Kim, Jian Hu, Lew Kaplan, Anna M. Pfaller, Nicole Schäfer, Volker Enzmann, Ursula Schlötzer-Schrehardt, Tobias Straub, Stefanie M. Hauck, Paul D. Gamlin, Michael B. McFerrin, Jeffrey Messinger, Christianne E. Strang, Christine A. Curcio, Nicholas Dana, Diana Pauly, Antje Grosche, Mingyao Li, Dwight Stambolian
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
single cell
complement
age-related macular degeneration
retina
RPE/choroid
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.895519/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.895519/full

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