The GCN2-ATF4 Signaling Pathway Induces 4E-BP to Bias Translation and Boost Antimicrobial Peptide Synthesis in Response to Bacterial Infection

The GCN2-ATF4 Signaling Pathway Induces 4E-BP to Bias Translation and Boost Antimicrobial Peptide Synthesis in Response to Bacterial Infection

Bacterial infection often leads to suppression of mRNA translation, but hosts are nonetheless able to express immune response genes through as yet unknown mechanisms. Here, we use a Drosophila model to demonstrate that antimicrobial peptide (AMP) production during infection is paradoxically stimulat...

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Bibliographic Details
Main Authors: Deepika Vasudevan, Nicholas K. Clark, Jessica Sam, Victoria C. Cotham, Beatrix Ueberheide, Michael T. Marr, II, Hyung Don Ryoo
Format: Article
Language:English
Published: Elsevier 2017-11-01
Series:Cell Reports
Subjects:
antimicrobial peptides
GCN2
ATF4
4E-BP
mRNA translation
innate immunity
5'
UTR
internal ribosome entry site
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717315760

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http://www.sciencedirect.com/science/article/pii/S2211124717315760

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