Activation of angiotensin-converting enzyme 2 produces an antidepressant-like effect via MAS receptors in mice

Activation of angiotensin-converting enzyme 2 produces an antidepressant-like effect via MAS receptors in mice

Abstract Angiotensin (Ang)-converting-enzyme (ACE) 2 converts Ang II into Ang (1–7), which in turn acts on MAS receptors (ACE2/Ang (1–7)/MAS receptors pathway). This pathway has neuroprotective properties, making it a potential therapeutic target for psychiatric disorders such as depression. Thus, w...

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Bibliographic Details
Main Authors: Osamu Nakagawasai, Kohei Takahashi, Taisei Koyama, Ryota Yamagata, Wataru Nemoto, Koichi Tan-No
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Molecular Brain
Subjects:
Antidepressant
Angiotensin-converting enzyme 2
Ang (1–7)
Diminazene
MAS receptor
Online Access:https://doi.org/10.1186/s13041-023-01040-y

Internet

https://doi.org/10.1186/s13041-023-01040-y

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