Follicular dendritic cell differentiation is associated with distinct synovial pathotype signatures in rheumatoid arthritis

Follicular dendritic cell differentiation is associated with distinct synovial pathotype signatures in rheumatoid arthritis

Follicular dendritic cells (FDCs) fundamentally contribute to the formation of synovial ectopic lymphoid-like structures in rheumatoid arthritis (RA) which is associated with poor clinical prognosis. Despite this critical role, regulation of FDC development in the RA synovium and its correlation wit...

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Bibliographic Details
Main Authors: Mohey Eldin M. El Shikh, Riham El Sayed, Nesreen Amer Ramadan Aly, Edoardo Prediletto, Rebecca Hands, Liliane Fossati-Jimack, Michele Bombardieri, Myles J. Lewis, Costantino Pitzalis
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Medicine
Subjects:
rheumatoid arthritis
synovial pathotypes
follicular dendritic cells (FDCs)
platelet-derived growth factor (PDGF)
tumor necrosis factor-α (TNF-α)
ectopic lymphoid-like structures (ELSs)
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.1013660/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2022.1013660/full

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