EZH2-Mediated H3K27me3 Targets Transcriptional Circuits of Neuronal Differentiation

EZH2-Mediated H3K27me3 Targets Transcriptional Circuits of Neuronal Differentiation

The Polycomb Repressive Complex 2 (PRC2) plays important roles in the epigenetic regulation of cellular development and differentiation through H3K27me3-dependent transcriptional repression. Aberrant PRC2 activity has been associated with cancer and neurodevelopmental disorders, particularly with re...

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Bibliographic Details
Main Authors: Serena Buontempo, Pasquale Laise, James M. Hughes, Sebastiano Trattaro, Vivek Das, Chantal Rencurel, Giuseppe Testa
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Neuroscience
Subjects:
EZH2 (enhancer of zeste homolog 2)
H3K27me3 – histone H3 tri-methylated at Lysine 27
neuronal differentiation
PRC2 (Polycomb repressive complex 2)
corticogenesis
epigenetics
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.814144/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2022.814144/full

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